INHIBITION OF DCLK1 KINASE REVERSES EPITHELIAL-MESENCHYMAL TRANSITION AND RESTORES T-CELL ACTIVITY IN PANCREATIC DUCTAL ADENOCARCINOMA

Inhibition of DCLK1 kinase reverses epithelial-mesenchymal transition and restores T-cell activity in pancreatic ductal adenocarcinoma

Immunotherapy has recently become a promising cancer therapy with extensive applications of immune checkpoint inhibitors (ICIs).However, pancreatic ductal adenocarcinoma (PDAC) appears to be kaiser copy stands unresponsive to immunotherapy due to the immunosuppressive microenvironment.Recent studies showed that cancer stem cell marker DCLK1 promote

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Normalizing flows for high-dimensional detector simulations

Whenever invertible generative networks are needed for LHC physics, normalizing flows show excellent performance.In this work, we investigate their 355 maybelline fit me performance for fast calorimeter shower simulations with increasing phase space dimension.We use fast and expressive coupling spline transformations applied to the CaloChallenge da

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